So far, only the substance known as “SARMs S4” (ANDARINE S4) has made it to the market, used by a limited number of professional and amateur bodybuilders.
The Gene Follistatin (FS344)
The road to big, strong muscles is long and requires hard work in a gym. But researchers may have found a shortcut where muscles grow on their own. Scientists have actually succeeded in increasing lean body mass and strength in macaque monkeys using gene therapy. The experiment was quite simple: the researchers injected the gene follistatin (FS344) directly into the monkeys’ right thigh muscles.
Follistatin was shown to block myostatin, a molecule that downregulates muscle growth but strengthens tendons. Eight weeks after the injection, the circumference of the monkeys’ right thigh muscles had increased by an average of 15 percent compared with the left thigh. A study conducted on two of the monkeys showed that muscle strength in the right leg had increased by 12 and 36 percent, respectively, compared to the untreated leg!
Follistatin is injected using a viral vector, which is an adeno-associated virus that serves as a delivery vehicle for the injected drug.
This is a common method called gene therapy and has been used in ligandrol-lgd-4033 humans with other drugs.
The study in the monkeys showed no negative side effects.
This therapy is being developed for use in patients with severe muscular dystrophy and other muscle wasting diseases.
Human clinical trials are scheduled to begin in 2011, and Nationwide Childrens Hospital in Ohio has already received funding for the study. There are a number of ongoing or planned studies and clinical trials for the treatment of muscle wasting diseases. Among the most interesting compounds are follistatin as an antagonist of myostatin,
Ostarine, a SARM
Ostarine, a SARM (Selective Androgen Receptor Modulator) currently being tested in human clinical trials by GTx Inc. and another SARM code-named BMS-564,929 being developed by Bristol-Myers Squibb.
The potential for abuse of these substances by athletes has led the World Anti-Doping Sarms kopen Agency to ban SARMs since 2008.
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